The Effect of Safranal on Th1/Th2 Cytokine Balance

Authors

  • Houshang Rafatpanah Buali Institute, Immunology Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Hossein Boskabady Neurogenic Inflammation Research Center, Department of Physiology, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  • Reza Feyzi Central Laboratory of Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  • Seyed Abdolrahim Rezaei Buali Institute, Immunology Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  • Seyedeh Masoumeh Seyed hosseini Tamijani Neurogenic Inflammation Research Center, Department of Physiology, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Background: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. Objective: To examine the effects of Safranal, a main constituent of Saffron stigma, on cell viability and cytokine profile of peripheral blood mononuclear cells (PBMC) were examined. Methods: Effects of Safranal at 0.1, 0.5 and 1 mM concentrations were evaluated on cell viability and production of interleukin 4 (IL-4), IL-10 and interferon-γ (IFN-γ) from non-stimulated and phytohemagglutinin (PHA) stimulated PBMCs, compared to 0.1 mM dexamethasone and saline. Results: In stimulated cells, different concentrations of Safranal caused significant decrease of lymphocytes viability (p

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the effect of safranal on th1/th2 cytokine balance

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volume 13  issue 4

pages  263- 273

publication date 2016-12-01

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